The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells

摘要

Here we demonstrate that the transforming growth factor-β (TGF-β) superfamily coreceptor, the type III TGF-β receptor, functions to suppress multiple myeloma disease progression through inhibition of multiple myeloma cell proliferation, heterotropic cell–cell adhesion, and migration, in a manner largely independent of its ligand presentation role.